m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT03220
|
[1] | |||
m6A modification
RNF2
RNF2
YTHDF1
 : m6A sites
Direct
Inhibition
Histone modification
H2AK119ub
RNF2
Downstream Gene
|
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | YTH domain-containing family protein 1 (YTHDF1) | READER | |||
| m6A Target | E3 ubiquitin-protein ligase RING2 (RNF2) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Histone modification (HistMod) | ||||
| Epigenetic Regulator | E3 ubiquitin-protein ligase RING2 (RNF2) | WRITER | View Details | ||
| Regulated Target | Histone H2A lysine 119 ubiquitination (H2AK119ub) | View Details | |||
| Crosstalk Relationship | m6A → Histone modification | Inhibition | |||
| Crosstalk Mechanism | m6A modification impacts directly histone modification through modulating the expression level of histone-associated enzymes | ||||
| Crosstalk Summary | YTHDF1, the N6-methyladenine (m6A) RNA reader that was previously known to be mainly cytoplasmic, associates with E3 ubiquitin-protein ligase RING2 (RNF2), a PRC1 protein that mediates Histone H2A lysine 119 ubiquitination (H2AK119ub) in human embryonic stem cells (hESCs). | ||||