m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT03189
 [1]
m6A modification HDAC4 HDAC4 ALKBH5 Demethylation : m6A sites Direct Enhancement Histone modification FOXO3 HDAC4 Downstream Gene
m6A Modification:
m6A Regulator RNA demethylase ALKBH5 (ALKBH5) ERASER
 Regulator Info 
m6A Target Histone deacetylase 4 (HDAC4)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Histone modification (HistMod)
Epigenetic Regulator Histone deacetylase 4 (HDAC4) ERASER View Details
Regulated Target Forkhead box protein O3 (FOXO3) View Details
Crosstalk Relationship m6A  →  Histone modification Enhancement
Crosstalk Mechanism m6A modification impacts directly histone modification through modulating the expression level of histone-associated enzymes
Crosstalk Summary ALKBH5 demethylates and stabilizes Hdac4 mRNA. Histone deacetylase 4 (HDAC4) interacts with and deacetylates Forkhead box protein O3 (FOXO3), resulting in a significant increase in FoxO3 expression
Responsed Disease Progressive muscular atrophy ICD-11: 8B60.3
 Disease Info 
Pathway Response FoxO signaling pathway hsa04068
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Histone deacetylase 4 (HDAC4) 104 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name PMID29671355-Compound-52 Patented [2]
MOA Inhibitor
Activity IC50 = 55 nM
External Link
CID: 117603070
TTD: D02YLT
 Compound Name PMID29671355-Compound-72a Patented [2]
MOA Inhibitor
Activity IC50 = 3 nM
External Link
TTD: D03KOH
 Compound Name PMID29671355-Compound-47c Patented [2]
MOA Inhibitor
Activity IC50 = 40 nM
External Link
CID: 72948227
TTD: D07KQB
 Compound Name PMID29671355-Compound-70 Patented [2]
MOA Inhibitor
Activity IC50 = 3 nM
External Link
CID: 122669618
TTD: D08CYC
 Compound Name PMID29671355-Compound-71b Patented [2]
MOA Inhibitor
Activity IC50 = 8 nM
External Link
TTD: D0BV4M
 Compound Name PMID29671355-Compound-72b Patented [2]
MOA Inhibitor
Activity IC50 = 21 nM
External Link
TTD: D0E7TU
 Compound Name PMID29671355-Compound-47a Patented [2]
MOA Inhibitor
Activity IC50 = 10 nM
External Link
CID: 72722126
TTD: D0L1NO
 Compound Name PMID29671355-Compound-50 Patented [2]
MOA Inhibitor
Activity IC50 = 12 nM
External Link
TTD: D0M7GG
 Compound Name PMID29671355-Compound-47b Patented [2]
MOA Inhibitor
Activity IC50 = 20 nM
External Link
CID: 72950863
TTD: D0NG9V
 Compound Name PMID29671355-Compound-71a Patented [2]
MOA Inhibitor
Activity IC50 = 3 nM
External Link
TTD: D0O1LX
 Compound Name PMID29671355-Compound-47d Patented [2]
MOA Inhibitor
Activity IC50 = 40 nM
External Link
CID: 72948224
TTD: D0SP7T
 Compound Name PMID29671355-Compound-12 Patented [2]
MOA Inhibitor
Activity IC50 = 120 nM
External Link
CID: 78425879
TTD: D0UE9B
 Compound Name PMID29671355-Compound-68b Patented [2]
MOA Inhibitor
Activity IC50 = 2.74 nM
External Link
TTD: D0GD6R
 Compound Name PMID29671355-Compound-45a Patented [2]
MOA Inhibitor
Activity IC50 = 49 nM
External Link
CID: 86302836
TTD: D0YN2T
 Compound Name PMID29671355-Compound-61 Patented [2]
MOA Inhibitor
Activity IC50 > 1000000 nM
External Link
TTD: D0JB4S
 Compound Name PMID29671355-Compound-23 Patented [2]
MOA Inhibitor
Activity IC50 = 3820 nM
External Link
CID: 118884610
TTD: D00HXJ
 Compound Name PMID29671355-Compound-56 Patented [2]
MOA Inhibitor
Activity IC50 = 9220 nM
External Link
CID: 56965342
TTD: D0CH8Q
 Compound Name PMID29671355-Compound-67 Patented [2]
MOA Inhibitor
Activity IC50 = 2840 nM
External Link
CID: 60201048
TTD: D0M0RE
 Compound Name PMID29671355-Compound-31 Patented [2]
MOA Inhibitor
Activity IC50 = 1970 nM
External Link
CID: 90479372
TTD: D0DI9S
DrugBank: DB14979
 Compound Name PMID29671355-Compound-21 Patented [2]
MOA Inhibitor
Activity IC50 = 16400 nM
External Link
CID: 86295624
TTD: D0LP1K
 Compound Name PMID29671355-Compound-62 Patented [2]
MOA Inhibitor
Activity IC50 = 100 to 500 nM
External Link
TTD: D07WAT
 Compound Name PMID29671355-Compound-43 Patented [2]
MOA Inhibitor
Activity IC50 > 100000 nM
External Link
CID: 118515590
TTD: D0BP8I
 Compound Name PMID29671355-Compound-25 Patented [2]
MOA Inhibitor
Activity IC50 = 3310 nM
External Link
CID: 126569528
TTD: D0RA0D
 Compound Name N-hydroxy-9,10-dihydroanthracene-9-carboxamide Investigative [3]
Synonyms
CHEMBL575482; SCHEMBL4541357
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 2320 nM
External Link
CID: 45482666
TTD: D03BQS
 Compound Name N-hydroxy-2,2-diphenylacetamide Investigative [3]
Synonyms
Diphenylacetohydroxamic acid; 4099-51-8; N-Hydroxy diphenylacetamide; CHEMBL396097; NSC44620; benzeneacetamide, n-hydroxy-; A-phenyl-; N-Hydroxydiphenylacetamide; BENZENEACETAMIDE,N-HYDROXY-A-PHENYL-; AC1Q5QC3; SCHEMBL2839032; CTK8I6435; DTXSID10286297; AC1L6390; ZINC4522248; NSC-44620; BDBM50207561; MFCD16314231; AKOS022308585; Diphenylacetohydroxamic acid, &gt
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 250 nM
External Link
CID: 239512
TTD: D03QOD
 Compound Name N-hydroxy-9H-xanthene-9-carboxamide Investigative [3]
Synonyms
CHEMBL583490; 9H-Xanthene-9-carboxamide,N-hydroxy-; SCHEMBL2843958; BDBM50300446
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 250 nM
External Link
CID: 44626296
TTD: D06IMY
 Compound Name 2,2-bis(3-fluorophenyl)-N-hydroxyacetamide Investigative [3]
Synonyms
CHEMBL574594; SCHEMBL4536216
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 700 nM
External Link
CID: 45482630
TTD: D0A4HF
 Compound Name AZUMAMIDE E Investigative [4]
Synonyms
CHEMBL402363
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 2280 nM
External Link
CID: 16095101
TTD: D0E9DD
 Compound Name 2,2-bis(4-fluorophenyl)-N-hydroxyacetamide Investigative [3]
Synonyms
CHEMBL573190; SCHEMBL2841871
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1100 nM
External Link
CID: 45482672
TTD: D0FN5D
 Compound Name N-hydroxy-2,2-diphenylpropanamide Investigative [3]
Synonyms
CHEMBL585365; SCHEMBL2844474
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 4500 nM
External Link
CID: 45482660
TTD: D0I4RK
 Compound Name AZUMAMIDE B Investigative [4]
Synonyms
CHEMBL402727
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 3660 nM
External Link
CID: 16095112
TTD: D0M1ZI
 Compound Name 2,2-bis(4-chlorophenyl)-N-hydroxyacetamide Investigative [3]
Synonyms
CHEMBL572805; SCHEMBL2848402
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 960 nM
External Link
CID: 45482643
TTD: D0PK9V
 Compound Name AZUMAMIDE C Investigative [4]
Synonyms
CHEMBL257972
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 3160 nM
External Link
CID: 16095114
TTD: D0Q9PO
 Compound Name LARGAZOLE Investigative [5]
Synonyms
CHEMBL1173445; (+)-Largazole; SCHEMBL71330; ZINC56861395
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 3000 nM
External Link
CID: 24757913
TTD: D0Z8PX
 Compound Name Cyclo(-L-Am7(S2Py)-L-A1in-L-Ala-D-Pro-) Investigative [6]
Synonyms
CHEMBL393260
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 25 nM
External Link
CID: 44437872
TTD: D00XTC
 Compound Name 7-mercapto-N-(4-phenylthiazol-2-yl)heptanamide Investigative [7]
Synonyms
CHEMBL419758; NCH-31; JMC505425 Compound 7; BDBM19131; 7-mercapto-N-(4-phenyl-2-thiazolyl)heptanamide; N-(4-phenyl-1,3-thiazol-2-yl)-7-sulfanylheptanamide
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 32 nM
External Link
CID: 11427204
TTD: D02HVH
 Compound Name Cyclo(-L-Am7(S2Py)-D-A1in-L-Ala-D-Pro-) Investigative [6]
Synonyms
CHEMBL390991
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 2.4 nM
External Link
CID: 44437870
TTD: D02NAF
 Compound Name Cyclo(-L-Am7(S2Py)-A2in-L-Ala-D-Pro-) Investigative [6]
Synonyms
CHEMBL394261
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1.6 nM
External Link
CID: 44437869
TTD: D02NVY
 Compound Name Cyclo(-L-Am7(S2Py)-Aib-L-Ph5-D-Pro-) Investigative [6]
Synonyms
CHEMBL391384
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 2.7 nM
External Link
CID: 44437878
TTD: D03PRG
 Compound Name Cyclo(-L-Am7(S2Py)-D-2MePhe-L-Ala-D-Pro-) Investigative [6]
Synonyms
CHEMBL393261
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 70 nM
External Link
CID: 44437873
TTD: D04CDZ
 Compound Name santacruzamate A Investigative [8]
Synonyms
CAY10683
    Click to Show/Hide
MOA Inhibitor
Activity IC50 > 1000 nM
External Link
CID: 72946782
TTD: D09RKA
 Compound Name Cyclo(-L-Am7(S2Py)-Aib-L-Ser(Bzl)-D-Pro-) Investigative [6]
Synonyms
CHEMBL241555
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1.6 nM
External Link
CID: 44437879
TTD: D0E8UH
 Compound Name Cyclo(-L-Am7(S2Py)-Aib-L-Phg-D-Pro-) Investigative [6]
Synonyms
CHEMBL428737
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 56 nM
External Link
CID: 44437876
TTD: D0G1EX
 Compound Name Cyclo(-L-Am7(S2Py)-Aib-L-Ala-D-Tic-) Investigative [6]
Synonyms
CHEMBL238587
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 4.2 nM
External Link
CID: 44437875
TTD: D0N5RV
 Compound Name Cyclo(-L-Am7(S2Py)-Aib-L-Ala-D-Pro-) Investigative [6]
Synonyms
CHEMBL238596; BDBM50222727
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 5.2 nM
External Link
CID: 44437883
TTD: D0R3XO
 Compound Name Cyclo(-L-Am7(S2Py)-Aib-L-Ser-D-Pro-) Investigative [6]
Synonyms
CHEMBL393961
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 4 nM
External Link
CID: 44437880
TTD: D0U0EZ
 Compound Name Cyclo(-L-Am7(S2Py)-Aib-L-Ph4-D-Pro-) Investigative [6]
Synonyms
CHEMBL391383
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 3.2 nM
External Link
CID: 44437877
TTD: D0X4QC
 Compound Name Cyclo(-L-Am7(S2Py)-L-2MePhe-L-Ala-D-Pro-) Investigative [6]
Synonyms
CHEMBL393464
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 2.2 nM
External Link
CID: 44437874
TTD: D0Z6HR
 Compound Name Cyclo(-L-Am7(S2Py)-Aib-L-Phe-D-Pro-) Investigative [6]
Synonyms
CHEMBL238829; BDBM50222732
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1.8 nM
External Link
CID: 44437868
TTD: D0Z6MI
 Compound Name TMP269 Investigative [9]
Synonyms
TMFO1; compound 1 [PMID: 23524983]; TMP-269; TMP 269
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 90.5 nM
External Link
CID: 53344908
TTD: D0R7JA
 Compound Name 8-Oxo-8-phenyl-octanoic acid hydroxyamide Investigative [10]
Synonyms
CHEMBL95959; SCHEMBL3383197; N-hydroxy-8-oxo-8-phenyloctanamide
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11075845
TTD: D0S0WK
 Compound Name ST-3050 Investigative [11]
Synonyms
CHEMBL472631; SCHEMBL3445133; SCHEMBL3445139; BDBM50278222
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 16100 nM
External Link
CID: 44591988
TTD: D01YBR
 Compound Name Octanedioic acid bis-hydroxyamide Investigative [12]
Synonyms
Suberohydroxamic acid
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 5173
TTD: D07YZZ
 Compound Name 9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide Investigative [10]
Synonyms
9,9,9-Trifluoro-8-Oxo-N-Phenylnonanamide; CHEMBL113537; 2gh6; SCHEMBL2702892; KRCXZGYVOZSCSF-UHFFFAOYSA-N; BDBM50121062; DB07553
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 5.1 nM
External Link
CID: 9882812
TTD: D00KFF
DrugBank: DB07553
 Compound Name 7-Mercapto-heptanoic acid phenylamide Investigative [13]
Synonyms
Thiol-SAHA (t-SAHA); CHEMBL325676; SCHEMBL14821761; BDBM152692
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11379392
TTD: D00SEE
 Compound Name 6-benzenesulfinylhexanoic acid hydroxamide Investigative [14]
Synonyms
6-(benzenesulfinyl)hexanoic acid hydroxyamide; 875737-03-4
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11694528
TTD: D00ZSD
 Compound Name N-(2-Mercapto-ethyl)-N'-phenyl-succinamide Investigative [15]
Synonyms
CHEMBL193959
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44401339
TTD: D01MFV
 Compound Name 7-Mercapto-heptanoic acid biphenyl-4-ylamide Investigative [13]
Synonyms
CHEMBL112311
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11220728
TTD: D01XWZ
 Compound Name N-Hydroxy-4-phenylacetylamino-benzamide Investigative [16]
Synonyms
CHEMBL356824; 656261-23-3; SCHEMBL675578; CTK1J6158; DTXSID40458440; ZINC13533297; AKOS030583151; Benzeneacetamide, N-[4-[(hydroxyamino)carbonyl]phenyl]-
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11196500
TTD: D01XXN
 Compound Name 6-(2-Bromo-acetylamino)-hexanoic acid phenylamide Investigative [13]
Synonyms
CHEMBL344920; 651767-99-6; SCHEMBL3736839; CTK1J8444; DTXSID50432973; HWYLREOMBVUGJQ-UHFFFAOYSA-N; BDBM50222416; ZINC13587789; AKOS030603042; N-Phenyl-6-(bromoacetylamino)hexanamide; Hexanamide, 6-[(bromoacetyl)amino]-N-phenyl-
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 9927379
TTD: D02MQM
 Compound Name N-Hydroxy-4-(phenylacetylamino-methyl)-benzamide Investigative [17]
Synonyms
CHEMBL143674; SCHEMBL673760
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11323577
TTD: D02UTC
 Compound Name 7-(Biphenyl-4-yloxy)-1-oxazol-2-yl-heptan-1-one Investigative [18]
Synonyms
CHEMBL126355; BDBM50222394
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44350626
TTD: D02WZK
 Compound Name Octanedioic acid hydroxyamide pyridin-4-ylamide Investigative [19]
Synonyms
SCHEMBL8082656; CHEMBL165162; ZINC13472304
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 10967421
TTD: D04GGW
 Compound Name N-(6-Mercapto-hexyl)-benzamide Investigative [13]
Synonyms
CHEMBL112364; BDBM50223650
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MOA Inhibitor
External Link
CID: 11447748
TTD: D04HSS
 Compound Name 4-Hydroxy-N-(5-hydroxycarbamoyl-pentyl)-benzamide Investigative [19]
Synonyms
CHEMBL167455
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MOA Inhibitor
External Link
CID: 11086699
TTD: D04NSP
 Compound Name N-Hydroxy-4-((R)-2-phenyl-butyrylamino)-benzamide Investigative [16]
Synonyms
SCHEMBL675474
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MOA Inhibitor
External Link
CID: 11231829
TTD: D04ZDI
 Compound Name 6-benzenesulfonylhexanoic acid hydroxamide Investigative [14]
Synonyms
CHEMBL203207
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MOA Inhibitor
External Link
CID: 11572583
TTD: D05AHZ
 Compound Name 9-(Biphenyl-4-yloxy)-1,1,1-trifluoro-nonan-2-one Investigative [10]
Synonyms
SCHEMBL7373122; CHEMBL116578
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MOA Inhibitor
External Link
CID: 44342872
TTD: D05FEJ
 Compound Name Thioacetic acid S-(6-phenylcarbamoyl-hexyl) ester Investigative [13]
Synonyms
CHEMBL111806; SCHEMBL14812153
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MOA Inhibitor
External Link
CID: 11254470
TTD: D05GVY
 Compound Name 4-Butyrylamino-N-hydroxy-benzamide Investigative [17]
Synonyms
CHEMBL142254; 656261-22-2; Benzamide, N-hydroxy-4-[(1-oxobutyl)amino]-; SCHEMBL675234; CTK1J6159; DTXSID90461262
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11287488
TTD: D05LLX
 Compound Name 7-(Naphthalen-2-yloxy)-1-oxazol-2-yl-heptan-1-one Investigative [18]
Synonyms
CHEMBL127328
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MOA Inhibitor
External Link
CID: 44350703
TTD: D05VFP
 Compound Name 7-Mercapto-heptanoic acid biphenyl-3-ylamide Investigative [13]
Synonyms
CHEMBL320323
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11449823
TTD: D05XAN
 Compound Name 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione Investigative [20]
MOA Inhibitor
External Link
CID: 3082127
TTD: D06IQB
 Compound Name N-Hydroxy-4-(2-phenyl-butyrylamino)-benzamide Investigative [16]
Synonyms
SCHEMBL676079
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11347053
TTD: D06VBN
 Compound Name 4-Dimethylamino-N-(6-mercapto-hexyl)-benzamide Investigative [13]
Synonyms
CHEMBL324126
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MOA Inhibitor
External Link
CID: 11277483
TTD: D06XNP
 Compound Name 7-Mercapto-heptanoic acid pyridin-3-ylamide Investigative [13]
Synonyms
CHEMBL332246; Heptanamide, 7-mercapto-N-3-pyridinyl-; BDBM50223653
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11345433
TTD: D07FJU
 Compound Name 6-Phenoxy-hexane-1-thiol Investigative [13]
Synonyms
CHEMBL109796; 6-phenoxyhexane-1-thiol; 1-Hexanethiol, 6-phenoxy-; SCHEMBL5679745; MolPort-020-180-823; BDBM50223652; AKOS018584222; MCULE-9521857089
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11298778
TTD: D09YBN
 Compound Name 4-Benzoylamino-N-hydroxy-benzamide Investigative [16]
Synonyms
SCHEMBL673678; CHEMBL191227
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MOA Inhibitor
External Link
CID: 11817702
TTD: D09ZNU
 Compound Name 4-Chloro-N-(5-hydroxycarbamoyl-pentyl)-benzamide Investigative [10]
Synonyms
CHEMBL143734; NSC718168; AC1L8L82; SCHEMBL13039735; ZINC5579677; BDBM50082664; NSC-718168; NCI60_040737; 6-(4-Chlorobenzoylamino)hexanehydroxamic acid
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 403373
TTD: D0A5LS
 Compound Name 8-(Biphenyl-4-yloxy)-1,1,1-trifluoro-octan-2-one Investigative [18]
Synonyms
CHEMBL112148; SCHEMBL7364383; BDBM50218532
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MOA Inhibitor
External Link
CID: 44341053
TTD: D0AX7B
 Compound Name 7-(Biphenyl-3-yloxy)-1-oxazol-2-yl-heptan-1-one Investigative [18]
Synonyms
CHEMBL127351; SCHEMBL7365180; HWZHDGRMABBYOV-UHFFFAOYSA-N; BDBM50222367; 7-((1,1'-biphenyl)-3-yloxy)-1-(1 ,3-oxazol-2-yl)-1-heptanone
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44350718
TTD: D0B2ZJ
 Compound Name 6-Mercapto-hexanoic acid phenylamide Investigative [13]
Synonyms
CHEMBL109654; Hexanamide, 6-mercapto-N-phenyl-; SCHEMBL14254925; BDBM50027600
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MOA Inhibitor
External Link
CID: 11436024
TTD: D0B3ZM
 Compound Name Cyclostellettamine derivative Investigative [21]
Synonyms
CHEMBL88332
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MOA Inhibitor
External Link
CID: 23327627
TTD: D0C0VP
 Compound Name N-(5-Hydroxycarbamoyl-pentyl)-4-nitro-benzamide Investigative [10]
Synonyms
CHEMBL139999; SCHEMBL1232700; BDBM50082661; ZINC13472309
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MOA Inhibitor
External Link
CID: 9943996
TTD: D0C2KD
 Compound Name 5-Mercapto-pentanoic acid phenylamide Investigative [13]
Synonyms
N-Phenyl-5-mercaptovaleramide; CHEMBL114344; Pentanamide, 5-mercapto-N-phenyl-
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11608171
TTD: D0D2KE
 Compound Name Octanedioic acid hydroxyamide pyridin-2-ylamide Investigative [19]
Synonyms
SCHEMBL8090513; CHEMBL164872; ZINC13472303
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MOA Inhibitor
External Link
CID: 11747496
TTD: D0E8KR
 Compound Name N-(2-Mercapto-ethyl)-N'-phenyl-oxalamide Investigative [15]
Synonyms
CHEMBL193979
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MOA Inhibitor
External Link
CID: 44401305
TTD: D0F0KS
 Compound Name 2-(methylsulfonylthio)ethyl 2-propylpentanoate Investigative [20]
Synonyms
CHEMBL271677; SCHEMBL4156413
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MOA Inhibitor
External Link
CID: 24759251
TTD: D0H1FZ
 Compound Name (E)-8-Biphenyl-4-yl-1-oxazol-2-yl-oct-7-en-1-one Investigative [18]
Synonyms
CHEMBL126465; SCHEMBL7368197; SCHEMBL7368201
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44350655
TTD: D0KE3I
 Compound Name N-Hydroxy-4-((S)-2-phenyl-butyrylamino)-benzamide Investigative [16]
Synonyms
SCHEMBL676080
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11312563
TTD: D0QO0L
 Compound Name N-Hydroxy-4-(3-phenyl-propionylamino)-benzamide Investigative [16]
Synonyms
N-hydroxy-4-(3-phenylpropanamido)benzamide
    Click to Show/Hide
MOA Inhibitor
External Link
TTD: D0R4BS
 Compound Name N-Hydroxy-4-(5-phenyl-pentanoylamino)-benzamide Investigative [16]
Synonyms
SCHEMBL7311087
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11472431
TTD: D0R5VG
 Compound Name 8-Oxo-8-phenyl-octanoic acid Investigative [19]
Synonyms
8-Oxo-8-phenyloctanoic acid; 7-Benzoylheptanoic acid; 24314-23-6; Benzeneoctanoic acid, h-oxo-; 7-BENZOYL HEPTANOIC ACID; AC1L6TSB; SCHEMBL3381106; 8-keto-8-phenyl-caprylic acid; CHEMBL162423; 8-Oxo-8-phenyloctanoic acid #; CTK4F3363; DTXSID40305602; UMCSRRHQLAVYRS-UHFFFAOYSA-N; ZINC2168376; 7009f; NSC171230; AKOS016022495; NSC-171230; MCULE-7202530747; ACM24314236; ST50825837
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 298878
TTD: D0RU1X
 Compound Name N-Hydroxy-4-(4-phenyl-butyrylamino)-benzamide Investigative [16]
Synonyms
CHEMBL143336; 656261-24-4; SCHEMBL674421; CTK1J6157; DTXSID30433908; ZINC13533300; AKOS030583673; n-hydroxy-4-(4-phenylbutyryl-amino)benzamide; Benzenebutanamide, N-[4-[(hydroxyamino)carbonyl]phenyl]-
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 9994848
TTD: D0S7WQ
 Compound Name 6-phenylsulfanylhexanoic acid hydroxamide Investigative [14]
Synonyms
Hexanamide, N-hydroxy-6-(phenylthio)-; CHEMBL203028; SCHEMBL7317658
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11637291
TTD: D0S9JF
 Compound Name ST-2987 Investigative [11]
Synonyms
CHEMBL471042; SCHEMBL3444989; SCHEMBL3444984; BDBM50278220
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 2040 nM
External Link
CID: 44138032
TTD: D0T0SK
 Compound Name 7-Mercapto-heptanoic acid quinolin-3-ylamide Investigative [13]
Synonyms
CHEMBL112234
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 10379373
TTD: D0T4IY
 Compound Name 5-(4-Chloro-phenyl)-pentanoic acid hydroxyamide Investigative [22]
Synonyms
CHEMBL84288
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11528707
TTD: D0V2ZO
 Compound Name 8-Mercapto-octanoic acid phenylamide Investigative [13]
Synonyms
8-mercapto-N-phenyloctanamide; CHEMBL326433; ZINC13609343
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11149404
TTD: D0XZ9Q
 Compound Name N-(6-Hydroxycarbamoyl-hexyl)-benzamide Investigative [19]
Synonyms
CHEMBL57107; 174664-71-2; SCHEMBL573254; CTK0A7470; DTXSID00433435; BDBM50220823; ZINC13490043; 7-(Benzoylamino)heptanehydroxamic acid; AKOS030580013; Benzamide, N-[7-(hydroxyamino)-7-oxoheptyl]-
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 9965141
TTD: D0YY9M
 Compound Name 7-(Biphenyl-4-yloxy)-1,1,1-trifluoro-heptan-2-one Investigative [10]
Synonyms
CHEMBL326529; SCHEMBL7365237; BDBM50217957
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44342825
TTD: D0Z3BM
 Compound Name 7-Mercapto-heptanoic acid benzothiazol-2-ylamide Investigative [13]
Synonyms
CHEMBL178779
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11346934
TTD: D0Z5KX
 Compound Name N-Hydroxy-4-(pentanoylamino-methyl)-benzamide Investigative [17]
Synonyms
CHEMBL143102
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44361923
TTD: D0Z7YS
 Compound Name PSAMMAPLIN A Investigative [10]
Synonyms
110659-91-1; Bisprasin; NSC614495; AC1O46WI; SCHEMBL364511; ZINC150352860; NSC-614495; B723735K022; J-002461; Benzenepropanamide, N,N'-(dithiodi-2,1-ethanediyl)bis(3-bromo-4-hydroxy-alpha-(hydroxyimino)-
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 6400741
TTD: D0N0TS
8B60: Motor neuron disease 70 Compound(s) Regulating the Disease Click to Show/Hide the Full List
 Compound Name AEN-100 Phase 4 [23]
Synonyms
Nobeldin; Nobelzin; Wilzin; NPC-02; Wilson's disease therapeutics, Nobel Pharma; Zinc acetate (Wilson's disease); Zinc acetate (Wilson's disease), Nobel Pharma/Orphan Europe/Teva; Zinc acetate (gastroretentive/ sustained-release/ tablet, amyotrophic lateral sclerosis), Adeona Pharmaceuticals
    Click to Show/Hide
External Link
TTD: D0Y5LR
 Compound Name Creatine ALS-08 Phase 3 [24]
Synonyms
Creatine; ALS-02; ALS-05; ALS-08; HD-02; PD-02; PD-04; PD-06; Creatine (ALS), Avicena; Creatine (amyotrophic lateral sclerosis), Avicena; PD-01, Avicena; AL-02 (ALS), Avicena; AL-08 (ALS), Avicena; Creatine (Huntington's disease), Avicena; Creatine (Parkinson's disease), Avicena
    Click to Show/Hide
External Link
CID: 586
TTD: D01WZG
DrugBank: DB00148
 Compound Name NT-KO-003 Phase 2 [25]
Synonyms
ATH-012; NT-K0-003
    Click to Show/Hide
External Link
TTD: D0Q0TI
 Compound Name CC-100 Phase 1 [26]
Synonyms
Fendosal; 53597-27-6; 5-(4,5-Dihydro-2-phenyl-3H-benz[e]indol-3-yl)salicylic acid; Alnovin; Fendosalum; HP 129; Fendosalum [INN-Latin]; UNII-9Z709558TZ; P 71-0129; C25H19NO3; NSC 351522; BRN 1665211; 2-hydroxy-5-(2-phenyl-4,5-dihydrobenzo[e]indol-3-yl)benzoic acid; 2-Hydroxy-5-(2-phenyl-4,5-dihydro-3H-benzo[e]indol-3-yl)benzoic acid; 3-(3-Carboxy-4-hydroxyphenyl)-2-phenyl-4,5-dihydro-3H-benz(e)indole; 5-(4,5-Dihydro-2-phenyl-3H-benz(e)indol-3-yl)-2-hydroxybenzoic acid; NSC351522; HP-129; 9Z709558TZ
    Click to Show/Hide
External Link
CID: 40821
TTD: D0UU1E
 Compound Name ISIS-SOD1 Phase 1 [27]
External Link
TTD: D05BYO
 Compound Name RG-7010 Phase 1 [28]
Synonyms
R-7010; PEGylated IGF1 (amyotrophic lateral sclerosis), Roche
    Click to Show/Hide
External Link
TTD: D03WNN
 Compound Name ORG-9273 Discontinued in Phase 2 [29]
Synonyms
1-[(2beta,3alpha,5alpha,16beta,17beta)-17-Acetoxy-3-hydroxy-2-morpholinoandrostan-16-yl]-1-methylpiperidinium bromide; 17beta-Acetoxy-3alpha-hydroxy-16beta-(1-methylhexahydropyridinio-1-yl)-2beta-morpholino-5alpha-androstane bromide
    Click to Show/Hide
External Link
CID: 131901
TTD: D0C2HR
 Compound Name ANQ-9040 Discontinued in Phase 1 [30]
Synonyms
3alpha-Acetoxy-3beta-(hexahydroazepinomethyl)-17a,17a-dimethyl-17-homo-17a-azonia-5alpha-androstane benzenesulfonate
    Click to Show/Hide
External Link
CID: 9939141
TTD: D0N1DQ
 Compound Name Celastrol Preclinical [31]
Synonyms
Tripterin; Tripterine; Celastrol, Celastrus scandens; (2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid; (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid; 3-Hydroxy-24-nor-2-oxo-1(10),3,5,7-friedelatetraen-29-oic Acid
    Click to Show/Hide
External Link
CID: 122724
TTD: D0I9XH
 Compound Name PLD-180 Terminated [32]
External Link
TTD: D0T9ZG
 Compound Name AX-205 Terminated [33]
External Link
TTD: D0D8ZU
 Compound Name TDI-0111 Investigative [34]
External Link
TTD: D0Z8UJ
 Compound Name TDI-0020 Investigative [34]
External Link
TTD: D0Z1HA
 Compound Name TDI-0046 Investigative [34]
External Link
TTD: D0Z0JA
 Compound Name Stem cell-derived astrocytes Investigative [34]
Synonyms
Stem cell-derived astrocytes (ALS)
    Click to Show/Hide
External Link
TTD: D0Y3XF
 Compound Name TDI-0113 Investigative [34]
External Link
TTD: D0XR6I
 Compound Name TDI-0098 Investigative [34]
External Link
TTD: D0X6DK
 Compound Name Cis-tetracosenoyl sulfatide Investigative [34]
Synonyms
Cis-tetracosenoyl sulfatide (amyotrophic lateral sclerosis); Cis-tetracosenoyl sulfatide (amyotrophic lateral sclerosis), Glycoregimmune
    Click to Show/Hide
External Link
CID: 5459361
TTD: D0X4FY
DrugBank: DB04661
 Compound Name TDI-0115 Investigative [34]
External Link
TTD: D0WT8Z
 Compound Name TDI-0043 Investigative [34]
External Link
TTD: D0W7NV
 Compound Name TDI-0107 Investigative [35]
Synonyms
Gene therapy (SOD1 gene inhibitor), ALS Therapy Development Foundation
    Click to Show/Hide
External Link
TTD: D0W7DP
 Compound Name NNZ-4945 Investigative [34]
Synonyms
Nerve regeneration program, Neuren/Metabolic Pharmaceuticals; Neurodegenerative disease peptides, Neuren/Metabolic Pharmaceuticals; Neuronal regeneration peptides (amyotrophic lateral sclerosis), CuroNZ; Neuronal regeneration peptides (motor neuron disease), CuroNZ; Neuronal regeneration peptides, Neuren/Calzada
    Click to Show/Hide
External Link
TTD: D0VO5V
 Compound Name NT-FV-007 Investigative [34]
External Link
TTD: D0U3DE
 Compound Name TDI-0103 Investigative [34]
External Link
TTD: D0TY1U
 Compound Name TDI-0114 Investigative [34]
External Link
TTD: D0T5JG
 Compound Name SCLERON Investigative [34]
Synonyms
Motoneuron degeneration blocker (amyotrophic lateral sclerosis), Lascco
    Click to Show/Hide
External Link
TTD: D0SI1Z
 Compound Name TDI-0047 Investigative [34]
External Link
TTD: D0SD8V
 Compound Name TDI-0033 Investigative [36]
Synonyms
Gene therapy program (NGF receptor agonist); TDI-0034; TDI-0035; TDI-0036; TDI-0038; TDI-0041; Gene therapy program (NGF receptor agonist), ALS Therapy Development Foundation
    Click to Show/Hide
External Link
TTD: D0Q8ZP
 Compound Name GEM-ALS Investigative [34]
Synonyms
Amyotrophic lateral sclerosis therapy (conjugated protein), Gemac
    Click to Show/Hide
External Link
TTD: D0PS2X
 Compound Name TDI-0042 Investigative [34]
External Link
TTD: D0PH0U
 Compound Name NsG-33 Investigative [34]
Synonyms
Meteorin
    Click to Show/Hide
External Link
TTD: D0M0JR
 Compound Name TDI-0066 Investigative [34]
External Link
TTD: D0LX4K
 Compound Name ETN-002 Investigative [34]
External Link
TTD: D0LR4M
 Compound Name TDI-0010 Investigative [34]
External Link
TTD: D0J2NI
 Compound Name TDI-0105 Investigative [34]
External Link
TTD: D0H2LJ
 Compound Name TDI-0029 Investigative [34]
External Link
TTD: D0GD6J
 Compound Name TDI-0049 Investigative [34]
External Link
TTD: D0FZ9N
 Compound Name TDI-0068 Investigative [34]
External Link
TTD: D0FK6A
 Compound Name AAV-IGF Investigative [34]
Synonyms
AAV-IGF (amyotrophic lateral sclerosis); AAV1-IGF-1; AAV-IGF (amyotrophic lateral sclerosis), Genzyme
    Click to Show/Hide
External Link
TTD: D0E9DP
 Compound Name TDI-0048 Investigative [34]
External Link
TTD: D0E2EN
 Compound Name TDI-0099 Investigative [34]
External Link
TTD: D0C4UU
 Compound Name TDI-0074 Investigative [34]
External Link
TTD: D0C3RP
 Compound Name TDI-0060 Investigative [35]
External Link
TTD: D0BT4P
 Compound Name TDI-0087 Investigative [34]
External Link
TTD: D09MPN
 Compound Name TDI-0026 Investigative [34]
External Link
TTD: D09LVK
 Compound Name TDI-0090 Investigative [34]
External Link
TTD: D09DHL
 Compound Name TDI-0039 Investigative [34]
External Link
TTD: D09BSI
 Compound Name TDI-0053 Investigative [34]
External Link
TTD: D07TWZ
 Compound Name TDI-0018 Investigative [34]
External Link
TTD: D07TIX
 Compound Name TDI-0032 Investigative [34]
External Link
TTD: D07MUT
 Compound Name TDI-0067 Investigative [34]
External Link
TTD: D07IYC
 Compound Name CERE-135 Investigative [34]
Synonyms
CERE-130; Insulin like growth factor-1 gene therapy, Ceregene; IGF-1 gene therapy (ALS), Ceregene; IGF-1 gene therapy (amyotrophic lateral sclerosis), Ceregene; AAV-IGF-1 gene therapy (ALS), Ceregene
    Click to Show/Hide
External Link
TTD: D06XPX
 Compound Name TDI-0028 Investigative [34]
Synonyms
ALS-TDI-00846
    Click to Show/Hide
External Link
TTD: D06VPT
 Compound Name TDI-0094 Investigative [34]
External Link
TTD: D06EYQ
 Compound Name ORG-9453 Investigative [34]
Synonyms
1-[3alpha-Acetoxy-17beta-butyryloxy-2beta-(piperidin-1-yl)-5alpha-androstan-16beta-yl]-1-methylpiperidinium bromide
    Click to Show/Hide
External Link
TTD: D06BHK
 Compound Name TDI-0025 Investigative [34]
External Link
TTD: D05YRG
 Compound Name TDI-0079 Investigative [35]
Synonyms
Superoxide dismutase-1 (SOD1) gene modulator (amyotrophic lateral sclerosis), ALS Therapy Development Foundation
    Click to Show/Hide
External Link
TTD: D05SCQ
 Compound Name RTA-801 Investigative [34]
External Link
TTD: D05GQV
 Compound Name TDI-0055 Investigative [34]
External Link
TTD: D05DZJ
 Compound Name TDI-0054 Investigative [34]
External Link
TTD: D04TPF
 Compound Name TDI-0059 Investigative [36]
External Link
TTD: D04LRQ
 Compound Name TDI-0102 Investigative [34]
External Link
TTD: D03JRL
 Compound Name TDI-0106 Investigative [34]
External Link
TTD: D02XUE
 Compound Name TDI-0015 Investigative [34]
External Link
TTD: D02TTP
 Compound Name TDI-0050 Investigative [34]
External Link
TTD: D02REO
 Compound Name MGN-8107 Investigative [34]
Synonyms
MiR-206 targeted therapeutic (amyotrophic lateral sclerosis), miRagen Therapeutics
    Click to Show/Hide
External Link
TTD: D02DZI
 Compound Name TDI-0065 Investigative [34]
External Link
TTD: D01PFX
 Compound Name TDI-0057 Investigative [34]
Synonyms
Gene therapy (cellular stress), ALS Therapy Development Foundation
    Click to Show/Hide
External Link
TTD: D00SNY
 Compound Name ALS-AAV9 Investigative [34]
Synonyms
Amyotrophic lateral sclerosis gene therapy, RegenX Biosciences; Adeno-associated virus vector-9 based gene therapy (injectable, ALS), RegenX Bioscience
    Click to Show/Hide
External Link
TTD: D00PGA
 Compound Name TDI-0051 Investigative [34]
External Link
TTD: D00HNQ
References
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Ref 11 N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2346-9. doi: 10.1016/j.bmcl.2009.02.029. Epub 2009 Feb 12.
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Ref 17 Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors. J Med Chem. 2004 Jan 15;47(2):467-74. doi: 10.1021/jm0303655.
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Ref 19 Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. doi: 10.1021/jm015568c.
Ref 20 New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1893-7. doi: 10.1016/j.bmcl.2008.02.007. Epub 2008 Feb 8.
Ref 21 Three new cyclostellettamines, which inhibit histone deacetylase, from a marine sponge of the genus Xestospongia. Bioorg Med Chem Lett. 2004 May 17;14(10):2617-20. doi: 10.1016/j.bmcl.2004.02.062.
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Ref 25 ClinicalTrials.gov (NCT01428726) A Phase IIa Study of NT-KO-003 for Multiple Sclerosis. U.S. National Institutes of Health.
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Ref 27 ClinicalTrials.gov (NCT01041222) Safety, Tolerability, and Activity Study of ISIS SOD1Rx to Treat Familial Amyotrophic Lateral Sclerosis (ALS) Caused by SOD1 Gene Mutations. U.S. National Institutes of Health.
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Ref 31 Emerging disease-modifying therapies for the treatment of motor neuron disease/amyotropic lateral sclerosis. Expert Opin Emerg Drugs. 2007 May;12(2):229-52.
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Ref 33 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018795)
Ref 34 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
Ref 35 Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide dismutase 1. Clin Cancer Res. 2006 Aug 15;12(16):4974-82.
Ref 36 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1888).