m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT03012
|
[1] | |||
m6A modification
p300
p300
METTL14
Methylation
 : m6A sites
Direct
Inhibition
Histone modification
H3K27me3
p300
Downstream Gene
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Methyltransferase-like 14 (METTL14) | WRITER | |||
| m6A Target | Histone acetyltransferase p300 (P300) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Histone modification (HistMod) | ||||
| Epigenetic Regulator | Histone acetyltransferase p300 (P300) | WRITER | View Details | ||
| Regulated Target | Histone H3 lysine 27 trimethylation (H3K27me3) | View Details | |||
| Crosstalk Relationship | m6A → Histone modification | Inhibition | |||
| Crosstalk Mechanism | m6A modification impacts directly histone modification through modulating the expression level of histone-associated enzymes | ||||
| Crosstalk Summary | The downregulation of CBP and Histone acetyltransferase p300 (P300) by METTL14 serves as a regulatory mechanism for the modulation of specific histone modifications, namely Histone H3 lysine 27 trimethylation (H3K27me3), H3K27ac, and H3K4me3. This regulatory action underscores the role of METTL14 in epigenetic control through the influence of m6A RNA methylation on histone modification patterns. | ||||
| In-vivo Model | Positive ES clones were used for injection into c57 blastocysts and generation of chimerical mice. To produce Mettl14f/+ mice, the chimeras were crossed with wild-type c57 for germ line transmission and then crossed with Atcb-Flpe transgenic mice (The Jackson Laboratory, # 003800) to remove FRT flanked selection cassette. Male Mettl14f/+ mice were crossed to female EIIa-Cre transgenic mice (The Jackson Laboratory, # 003724) to obtain Mettl14+/mice, and Mettl14+/ mice were intercrossed to obtain Mettl19-conventional knockout mice. Sex of embryos was determined. | ||||
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
| Histone acetyltransferase p300 (P300) | 2 Compound(s) Regulating the Target | Click to Show/Hide the Full List | ||
 Compound Name |
CCS1477 | Phase 1/2 | [2] | |
|---|---|---|---|---|
| Synonyms |
CCS-1477; CBP-IN-1; 2222941-37-7; (S)-1-(3,4-Difluorophenyl)-6-(5-(3,5-dimethylisoxazol-4-yl)-1-((1r,4S)-4-methoxycyclohexyl)-1H-benzo[d]imidazol-2-yl)piperidin-2-one; SCHEMBL20094038; SCHEMBL21515367; SCHEMBL22134021; EX-A3687; NSC818619; NSC-818619; HY-111784; CS-0091862; (S)-1-(3,4-Difluorophenyl)-6-(5-(3,5-dimethylisoxazol-4-yl)-1-(trans-4-methoxycyclohexyl)-1H-benzo[d]imidazol-2-yl)piperidin-2-one
Click to Show/Hide
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| MOA | Inhibitor | |||
| External Link | ||||
| Compound Name |
FT-7051 | Phase 1 | [3] | |
| MOA | Inhibitor | |||
| External Link | ||||
References