m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT02011
|
[1] | |||
m6A modification
TET1
TET1
YTHDF2
 : m6A sites
Direct
Inhibition
DNA methylation
TET1
METTL3
|
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | YTH domain-containing family protein 2 (YTHDF2) | READER | |||
| m6A Target | Methylcytosine dioxygenase TET1 (TET1) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | DNA methylation (DNAMeth) | ||||
| Epigenetic Regulator | Methylcytosine dioxygenase TET1 (TET1) | ERASER | View Details | ||
| Regulated Target | Methyltransferase-like protein 3 (METTL3) | View Details | |||
| Crosstalk Relationship | m6A → DNA methylation | Inhibition | |||
| Crosstalk Mechanism | m6A modification directly impacts DNA methylation through modulating the expression level of DNA methyltransferases or demethylases. | ||||
| Crosstalk Summary | Our study revealed that Methyltransferase-like protein 3 (METTL3) targeted Methylcytosine dioxygenase TET1 (TET1) mRNA via m6A methylation in a YTHDF2 dependent manner, and TET1, in turn, mediated DNA methylation targeting METTL3 to affect mRNA m6A methylation, thus forming a negative feedback loop that regulated myoblast differentiation. | ||||
| Cell Process | mRNA stability | ||||
| Cell differentiation | |||||