m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT00628
 [1], [2], [3]
RNA modification NEAT1 NEAT1 ADAR Methylation : modification sites Indirect Enhancement m6A modification hsa-mir-146a hsa-mir-146a METTL14 Methylation : m6A sites
m6A Modification:
m6A Regulator Methyltransferase-like 14 (METTL14) WRITER
 Regulator Info 
m6A Target hsa-mir-146a
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type RNA modification (RNAMod)  >> Adenosine-to-Inosine editing (A-to-I)
Epigenetic Regulator Interferon-inducible protein 4 (ADAR1) WRITER View Details
Regulated Target Nuclear paraspeckle assembly transcript 1 (NEAT1) View Details
Crosstalk Relationship A-to-I  →  m6A Enhancement
Crosstalk Mechanism RNA modification indirectly impacts m6A modification through downstream signaling pathways
Crosstalk Summary ADAR1 interacts with Nuclear paraspeckle assembly transcript 1 (NEAT1), increasing it's A-to-I level and promoting its physical interaction with hsa-mir-146a, which was regulated by METTL14-mediated m6A modification.
In-vitro Model
 HUVEC-C Normal Homo sapiens CVCL_2959
MDA-MB-231 Breast adenocarcinoma Homo sapiens CVCL_0062
MCF-7 Invasive breast carcinoma Homo sapiens CVCL_0031
References
Ref 1 Adenosine-to-inosine Alu RNA editing controls the stability of the pro-inflammatory long noncoding RNA NEAT1 in atherosclerotic cardiovascular disease. J Mol Cell Cardiol. 2021 Nov;160:111-120. doi: 10.1016/j.yjmcc.2021.07.005. Epub 2021 Jul 21.
Ref 2 METTL14 promotes the migration and invasion of breast cancer cells by modulating N6?methyladenosine and hsa?miR?146a?5p expression. Oncol Rep. 2020 May;43(5):1375-1386. doi: 10.3892/or.2020.7515. Epub 2020 Feb 24.
Ref 3 Receptor tyrosine kinase ROR1 ameliorates Abeta(1-42) induced cytoskeletal instability and is regulated by the miR146a-NEAT1 nexus in Alzheimer's disease. Sci Rep. 2021 Sep 28;11(1):19254. doi: 10.1038/s41598-021-98882-0.