m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT00474
|
[1], [2], [3] | |||
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.png)
 : m6A sites
Indirect
Inhibition
RNA modification
MIR181A1
MIR181A1
ADAR
Methylation
 : modification sites
|
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Methyltransferase-like 14 (METTL14) | WRITER | |||
| m6A Target | Nuclear paraspeckle assembly transcript 1 (NEAT1) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | RNA modification (RNAMod) >> Adenosine-to-Inosine editing (A-to-I) | ||||
| Epigenetic Regulator | Interferon-inducible protein 4 (ADAR1) | WRITER | View Details | ||
| Regulated Target | MicroRNA 181a-1 (MIR181A1) | View Details | |||
| Crosstalk Relationship | m6A → A-to-I | Inhibition | |||
| Crosstalk Mechanism | m6A modification indirectly impacts RNA modification through downstream signaling pathways | ||||
| Crosstalk Summary | METTL14 interacts with Nuclear paraspeckle assembly transcript 1 (NEAT1), increasing its m6A level and inhibiting its physical interaction with MicroRNA 181a-1 (MIR181A1), which was regulated by ADAR1-mediated A-to-I modification. | ||||
In-vitro Model |
769-P | Renal cell carcinoma | Homo sapiens | CVCL_1050 | |
| 786-O | Renal cell carcinoma | Homo sapiens | CVCL_1051 | ||
| CAL-27 | Tongue squamous cell carcinoma | Homo sapiens | CVCL_1107 | ||
| HN4 | Clear cell renal cell carcinoma | Homo sapiens | CVCL_IS30 | ||
References