m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT00471
|
[1], [2], [3] | |||
.png)
.png)
 : m6A sites
Indirect
Enhancement
RNA modification
MIR149
MIR149
ADAR
Methylation
 : modification sites
|
|||||
| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Methyltransferase-like 14 (METTL14) | WRITER | |||
| m6A Target | KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | RNA modification (RNAMod) >> Adenosine-to-Inosine editing (A-to-I) | ||||
| Epigenetic Regulator | Interferon-inducible protein 4 (ADAR1) | WRITER | View Details | ||
| Regulated Target | MicroRNA 149 (MIR149) | View Details | |||
| Crosstalk Relationship | m6A → A-to-I | Enhancement | |||
| Crosstalk Mechanism | m6A modification indirectly impacts RNA modification through downstream signaling pathways | ||||
| Crosstalk Summary | METTL14 interacts with KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1), increasing its m6A level and promoting its physical interaction with MicroRNA 149 (MIR149), which was regulated by ADAR1-mediated A-to-I modification. | ||||
In-vitro Model |
AC16 [Human hybrid cardiomyocyte] | Normal | Homo sapiens | CVCL_4U18 | |
| BRO | Amelanotic melanoma | Homo sapiens | CVCL_7036 | ||
References