m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT00435
|
[1], [2], [3], [4] | |||
.png)
.png)
 : m6A sites
Indirect
Inhibition
RNA modification
MIR125A
MIR125A
METTL1
Methylation
 : modification sites
|
|||||
| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Methyltransferase-like 14 (METTL14) | WRITER | |||
| m6A Target | Nuclear paraspeckle assembly transcript 1 (NEAT1) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | RNA modification (RNAMod) >> N7-methylguanosine (m7G) | ||||
| Epigenetic Regulator | Methyltransferase-like protein 1 (METTL1) | WRITER | View Details | ||
| Regulated Target | MicroRNA 125a (MIR125A) | View Details | |||
| Crosstalk Relationship | m6A → m7G | Inhibition | |||
| Crosstalk Mechanism | m6A modification indirectly impacts RNA modification through downstream signaling pathways | ||||
| Crosstalk Summary | METTL14 interacts with Nuclear paraspeckle assembly transcript 1 (NEAT1), increasing its m6A level and inhibiting its physical interaction with MicroRNA 125a (MIR125A), which was regulated by METTL1-mediated m7G modification. | ||||
In-vitro Model |
769-P | Renal cell carcinoma | Homo sapiens | CVCL_1050 | |
| 786-O | Renal cell carcinoma | Homo sapiens | CVCL_1051 | ||
| A-549 | Lung adenocarcinoma | Homo sapiens | CVCL_0023 | ||
References