m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT00419				[1], [2], [3], [4]
RNA modification MIR21 MIR21 ADARB1 Methylation : modification sites Indirect Inhibition m⁶A modification RUNX1 RUNX1 YTHDF2 : m⁶A sites
m6A Regulator	YTH domain-containing family protein 2 (YTHDF2)			READER	Regulator Info
m6A Target	Runt-related transcription factor 1 (RUNX1)				Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	RNA modification (RNAMod) >> Adenosine-to-Inosine editing (A-to-I)
Epigenetic Regulator	Double-stranded RNA-specific editase 1 (ADARB1)			WRITER	View Details
Regulated Target	MicroRNA 21 (MIR21)				View Details
Crosstalk Relationship	A-to-I → m6A			Inhibition
Crosstalk Mechanism	RNA modification indirectly impacts m6A modification through downstream signaling pathways
Crosstalk Summary	ADARB1 interacts with MicroRNA 21 (MIR21), increasing it's A-to-I level and inhibiting its physical interaction with Runt-related transcription factor 1 (RUNX1), which was regulated by YTHDF2-mediated m6A modification.
In-vitro Model	HSC (Hematopoietic stem cell)
In-vitro Model	U-118MG	Astrocytoma	Homo sapiens		CVCL_0633

References

Ref 1	Suppression of m(6)A reader Ythdf2 promotes hematopoietic stem cell expansion. Cell Res. 2018 Sep;28(9):904-917. doi: 10.1038/s41422-018-0072-0. Epub 2018 Jul 31.
Ref 2	Modulation of microRNA editing, expression and processing by ADAR2 deaminase in glioblastoma. Genome Biol. 2015 Jan 13;16(1):5. doi: 10.1186/s13059-014-0575-z.
Ref 3	The Role of ADAR1 and ADAR2 in the Regulation of miRNA-21 in Idiopathic Pulmonary Fibrosis. Lung. 2018 Aug;196(4):393-400. doi: 10.1007/s00408-018-0115-9. Epub 2018 Apr 10.
Ref 4	miR-21 regulates immunosuppression mediated by myeloid-derived suppressor cells by impairing RUNX1-YAP interaction in lung cancer. Cancer Cell Int. 2020 Oct 12;20:495. doi: 10.1186/s12935-020-01555-7. eCollection 2020.