m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT00408
 [1], [2], [3], [4], [5], [6], [7]
m6A modification GAS5 GAS5 YTHDF3 : m6A sites Indirect Inhibition RNA modification MIR21 MIR21 ADAR Methylation : modification sites
m6A Modification:
m6A Regulator YTH domain-containing family protein 3 (YTHDF3) READER
 Regulator Info 
m6A Target Growth arrest specific 5 (GAS5)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type RNA modification (RNAMod)  >> Adenosine-to-Inosine editing (A-to-I)
Epigenetic Regulator Interferon-inducible protein 4 (ADAR1) WRITER View Details
Regulated Target MicroRNA 21 (MIR21) View Details
Crosstalk Relationship m6A  →  A-to-I Inhibition
Crosstalk Mechanism m6A modification indirectly impacts RNA modification through downstream signaling pathways
Crosstalk Summary YTHDF3 interacts with Growth arrest specific 5 (GAS5), increasing its m6A level and inhibiting its physical interaction with MicroRNA 21 (MIR21), which was regulated by ADAR1-mediated A-to-I modification.
In-vitro Model
 HCT 116 Colon carcinoma Homo sapiens CVCL_0291
RKO Colon carcinoma Homo sapiens CVCL_0504
HN4 Clear cell renal cell carcinoma Homo sapiens CVCL_IS30
CAL-27 Tongue squamous cell carcinoma Homo sapiens CVCL_1107
References
Ref 1 Long noncoding RNA GAS5 inhibits progression of colorectal cancer by interacting with and triggering YAP phosphorylation and degradation and is negatively regulated by the m(6)A reader YTHDF3. Mol Cancer. 2019 Oct 16;18(1):143. doi: 10.1186/s12943-019-1079-y.
Ref 2 The Role of ADAR1 and ADAR2 in the Regulation of miRNA-21 in Idiopathic Pulmonary Fibrosis. Lung. 2018 Aug;196(4):393-400. doi: 10.1007/s00408-018-0115-9. Epub 2018 Apr 10.
Ref 3 ADAR1 promotes the epithelial-to-mesenchymal transition and stem-like cell phenotype of oral cancer by facilitating oncogenic microRNA maturation. J Exp Clin Cancer Res. 2019 Jul 17;38(1):315. doi: 10.1186/s13046-019-1300-2.
Ref 4 lncRNA GAS5 acts as a ceRNA for miR-21 in suppressing PDGF-bb-induced proliferation and migration in vascular smooth muscle cells. J Cell Biochem. 2019 Sep;120(9):15233-15240. doi: 10.1002/jcb.28789. Epub 2019 May 8.
Ref 5 Long Noncoding RNA GAS5 Acts As A Tumor Suppressor In Laryngeal Squamous Cell Carcinoma Via miR-21. Cancer Manag Res. 2019 Sep 17;11:8487-8498. doi: 10.2147/CMAR.S213690. eCollection 2019.
Ref 6 Long noncoding RNA GAS5 induces abdominal aortic aneurysm formation by promoting smooth muscle apoptosis. Theranostics. 2019 Jul 28;9(19):5558-5576. doi: 10.7150/thno.34463. eCollection 2019.
Ref 7 GAS5/miR-21 Axis as a Potential Target to Rescue ZCL-082-Induced Autophagy of Female Germline Stem Cells In?Vitro. Mol Ther Nucleic Acids. 2019 Sep 6;17:436-447. doi: 10.1016/j.omtn.2019.06.012. Epub 2019 Jun 28.