m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT00062
|
[1] | |||
.png)
.png)
 : m6A sites
Direct
Enhancement
RNA modification
PSMB2
PSMB2
ADAR1
Methylation
 : modification sites
|
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | YTH domain-containing family protein 1 (YTHDF1) | READER | |||
| m6A Target | Interferon-inducible protein 4 (ADAR1) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | RNA modification (RNAMod) >> Adenosine-to-Inosine editing (A-to-I) | ||||
| Epigenetic Regulator | Interferon-inducible protein 4 (ADAR1) | WRITER | View Details | ||
| Regulated Target | Proteasome 20S subunit beta 2 (PSMB2) | View Details | |||
| Crosstalk Relationship | m6A → A-to-I | Enhancement | |||
| Crosstalk Mechanism | m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator | ||||
| Crosstalk Summary | The A-to-I RNA editing activity of Interferon-inducible protein 4 (ADAR1) plays important roles in the YTHDF1-dependent IFN responses. Therefore, m6A and YTHDF1 affect innate immune responses through modulating the ADAR1-mediated A-to-I RNA editing of mRNA (TNKS; EIF2AK2 and Proteasome 20S subunit beta 2 (PSMB2)). | ||||
In-vitro Model |
A-172 | Glioblastoma | Homo sapiens | CVCL_0131 | |
| LN-229 | Glioblastoma | Homo sapiens | CVCL_0393 | ||
| Vero | Normal | Chlorocebus sabaeus | CVCL_0059 | ||