m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT00025				[1]
RNA modification Circ_SLC45A4 Circ_SLC45A4 TRMT6 Methylation : modification sites Direct Enhancement m⁶A modification Circ_SLC45A4 Circ_SLC45A4 YTHDF2 : m⁶A sites
m6A Regulator	YTH domain-containing family protein 2 (YTHDF2)			READER	Regulator Info
m6A Target	Circ_SLC45A4				Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	RNA modification (RNAMod) >> N1-methyladenosine (m1A)
Epigenetic Regulator	tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 (TRMT6)			WRITER	View Details
Regulated Target	Circ_SLC45A4				View Details
Crosstalk Relationship	m1A → m6A			Enhancement
Crosstalk Mechanism	RNA modification directly impacts m6A modification through recruiting m6A regulator and targeting the shared RNA
Crosstalk Summary	A subset of endogenous RNAs (cMATR3; cFAM20B and Circ_SLC45A4) that harbor m6A and associate with YTHDF2 in an HRSP12-dependent manner is also subjected to m1A-facilitated rapid degradation. The m1A modification is mediated by the TRMT6/TRMT61A complex.
Pathway Response	RNA degradation				hsa03018
Cell Process	mRNA decay
In-vitro Model	HeLa	Endocervical adenocarcinoma	Homo sapiens		CVCL_0030

References

Ref 1	m(1)A and m(6)A modifications function cooperatively to facilitate rapid mRNA degradation. Cell Rep. 2022 Sep 6;40(10):111317. doi: 10.1016/j.celrep.2022.111317.